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耳针和六味地黄丸加味预防和治疗去势雌鼠骨质疏松的实验研究罗小光 刘国忠 指导:贺志光 吕明庄


  (贵阳医学院附属医院,贵州550004)

  [摘 要] 目的:探讨耳针和中药六味地黄丸加味对绝经后骨质疏松症的防治作用及其作用机理。方法:取66只SD雌性大鼠按体重随机分为6组:假手术组、模型组、耳针组、中药组、耳针十中药组、西药组。后4组分别经耳针、六味地黄丸加味、耳针加中药联合应用以及雌二醇治疗3个月,观察耳针及中药对去势雌鼠的影响。

  结论:耳针、中药皆能提高去势雌鼠的BMC、BMD,防治PMO。

  [主题词] 阉割/骨质疏松绝经后/预防和控制;耳针;六味地黄汤/治疗应用ExperimentalStudyonPreventionandTreatmentofOsteoporosisinOvariectomized

RatswithAuricularAcupunctureandModifiedLiuweiDihuangPillLuoXiaoguangLiuGuozhong,HeZhigu

ang,etal(GuiyangMedicalCollege,Guizhou550004)

  [Abstract] Purpose ToexplorepreventionandtreatmentactionsofauricularacupunctureandmodifiedLiuweiDihuangPillonpostmenopausalosteoporosisandtheirmechanisms.Methods Sixtysixfemaleratswererandomlydividedintosixgroupsaccordingtotheirbodyweight,pse

udooperationgroup(POG),modelgroup(MG),auricularacupuncturegroup

(AAG),Chineseherbgroup(CHG),auricularacupunctureplusChineseherbgroup(AHG)andestrogengroup(EG).ExceptforthePOG,allthegroupswereovariectomized.Aftertheoperation

,AAG,CHG,AHGandEGweretreatedrespectivelywithauricularacupuncture,LiuweiDihuangPill(LWP),auricularacupuncturecombinedwithLiuweiDihuangPill,andestradiolbenzoas.Threemonthslater,theeffectsofauricularacupu

nctureandLiuweiDihuangPillontheratswereobserved.Results BothauricularacupunctureandLWPcanpromoteBMCandBMDinovariectomizedrats,soastop

reventandtreatPMO.Themechanismmaybeincreaseserumestrogenlevel,decrea

seserumPTHlevelandraiseCTlevel,inhibitingboneresorption,increasingbonereformatio

nanddecreasingbonereabsorptionandthenadjustingimbalanceofbonemetabolism.

  [Keywords] Castration,Osteoporosis,Postmenopausal/prev;AuricularAcupuncture;LiuweiDihuan

gDecoction/theruse

  绝经后骨质疏松症(PostmenopausalOsteoporosis,PMO)是绝经后妇女的易患疾病。

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