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脑内阿片受体介导电针“曲池”“听宫”的降压及降心率效应 邹长江 王 慧 给 娜


  (1.北京大学医学部生理学和病理生理学系,100083;2.贵阳中医学院生理教研室,3.新疆伊宁卫生学校生理教研室)

  [摘 要] 

  目的:检测2 Hz电针"曲池""听宫"穴的降压和降心 率反应与脑室注射阿片受体兴奋剂双氢埃托菲的降压和降心率反应的异同。

  方法:用乌拉坦麻醉大鼠,脑室注射阿片受体拮抗剂、阿片受 体兴奋剂,电针"曲池""听宫"穴。

  结果:(1)电针"曲池""听宫"穴的降压及降心率反应 被 脑室注射阿片受体阻断剂纳络酮衰减,但不被脊髓蛛网膜下腔注射纳络酮衰减。(2) 脑室 注射阿片受体兴奋剂双氢埃托菲出现明显的剂量依赖的降压及降心率效应,其降压效应 被脊髓蛛网膜下腔注射纳络酮衰减,但不受切断双侧颈迷走神经的影响。

  结论:(1)脑内阿片受体部分介导电针"曲池""听宫" 穴 的降压效应及降心率效应;(2)中枢阿片受体兴奋产生降压效应,脊髓内的阿片受体介导 此降压效应。

  [主题词] 埃托菲;电针;血压/针灸效应;心率/针灸效 应

  DepressorBradycardia Effect of A cupuncture at "Quchi" and "Tinggong"Poin ts are Mediated by Opiate Receptor in Br ain

  Zou Changjiang1,Wang Hui2,Ji N a3

  (1.Department of Physiology and Pa th ophysiology,Medical College,Beijing Univ ersity,Beijing 100083;2.Teaching and Res earch Section of Physiology,Guiyang Coll ege of TCM;3.Teaching and Research Secti on of Physiology,Xinjiang Yining Health School)

  [Abstract] 

  Purpose To compare the d epressorbradycardia effect of electroac upuncture at 2 Hz with that of intraven tricular injection of dihydroetorphine,a stimulant of opiate receptor.

  Methods  Intraventricular injection of inhibitor and stimulant of opiate receptor were respectivelygiven into the rat anesthetized by urethane,an d electroacupuncture was applied to "Quc hi"(LI 11)and "Tinggong"(SI 19)points.

  Results The depressorbr adycardia effect of electroacupuncture w as reduced by cerebroventricular injecti on of naloxone,an inhibitor of opiate re ceptor,but was not reduced by injection of naloxone into spinal subarachnoid spa ce;Cerebroventricular injection of dihyd roetorphine induced obvious dosedepen d ent depressorbradycardia effect,and the depressor effect was reduced by injecti on of naloxone into spinal subarachnoid space,but was not influenced by section of bilateral cervical vagus nerves.

  Conclusion Opiate recept or in brain mediates partially the depre ssorbradycardia effect of electroacupun cture;Excitation of central opiate recep tor induces depressor effect and spinal opiate receptor mediates the depressor e ffect.

  [Key words] Etorphine;El ectroacupuncture;Blood pressure/acup eff ;Heart rate/acup eff

  卫生部优秀青年科技人才专项科研基金

  电针"曲池""听宫"穴可引起较强的降压及降心率反应[1, 2]。

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