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217例儿科头孢曲松与其他药物联合使用不良反应报告分析


作者单位:1.中国药科大学,江苏南京210009; 2.江苏省药品不良反应监测中心,江苏南京210002;

【摘要】    目的 探讨儿科头孢曲松合并用药不良反应发生情况,为临床合理用药提供参考。方法 对2004—2007年江苏省药品不良反应监测中心数据库中儿科头孢曲松合并用药不良反应病例报告进行分类统计。结果 217例合并用药不良反应病例中,排名前3位的药品种类分别是调节水电解质及酸碱平衡药物(30.88%)、抗病毒类药物(20.74%)、中药注射剂(18.89%);排名前3位的伍用药品分别是利巴韦林(21.05%)、氯化钠(20.53%)、地塞米松(16.84%)。8例严重不良反应病例中的3例死亡,分别为三联或四联用药。结论 临床应重视儿科头孢曲松的联合用药,警惕可能因不合理的联合用药诱发严重不良反应。

【关键词】  头孢曲松 联合用药 不良反应 儿童

  analysis of 217 pediatrical adr case reports of cefatriaxone in combination with other drugs

  xu houming1, 2, liu xiaorui3, sun jun2, liu naifeng4

  (1. china pharmaceutical university, nanjing, jiangsu 210009, china; 2. center for adr monitoring of jiangsu, nanjing, jiangsu 210002; 3. grade 2003, department of  clinical pharmacy, xuzhou medical college,

  xuzhou, jiangsu 221002;4. affiliated zhongda hospital, southeast university, nanjing, jiangsu 210009)

  abstract: objective  to investigate the cause and influencing factor of adverse drug reaction (adr) of cefatriaxone in combination with other drugs in department of pediatrics, and to provide reference for the clinical drug administration. methods  a retrospective research of case reports on adverse drug reactions (adr) caused by cefatriaxone in combination with other drugs from 2004 to 2007 in the database of center for adr monitoring of jiangsu was performed for categorization and statistical analysis. results  of the total 217 adr reports, medication adjusting water, the electrolyte and the acid-base equilibrium (30.88%), antiviral drugs (20.74%) and traditional chinese drug injections (18.89%) are the top 3 drug types, and the top 3 drugs were ribavirin (21.05%), sodium chloride (20.53%) and dexamethasone (16.84%). 8 cases were serious adrs in 217 reports, in which there were 3 deaths, caused by triple or quadruple medication respectively. conclusion  in clinical administration of cefatriaxone in pediatrics, precautions should be taken to prevent the potential risks of severe adverse reactions induced by inappropriate combination with other drugs.

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