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针刺对胚胎移植怀孕率的影响及其机理:随机安慰对照研究张明敏等


  (1.华中科技大学同济医学院附属同济医院,湖北 武汉 430030; 2.德国乌尔姆生殖医学研究所)

  [摘要]目的:采用随机、安慰对照的研究方法,探讨在胚胎移植前后行针刺治疗在助孕技术中,如体外受精(IVF)或卵母细胞单精子注射(ICSI),对怀孕率的影响及其机理。方法:对210例接受IVF或ICSI的患者按完全随机的方法分成针刺治疗组、安慰针灸组和空白对照组,针刺治疗组在胚胎移植前后行体针针刺进行干预,安慰针灸组在胚胎移植前后用安慰针灸针进行干预,空白对照组未经过针灸治疗,观察3组子宫结合带的收缩频率及怀孕率。结果:胚胎移植前子宫结合带收缩频率3组间差异无显着性意义,胚胎移植后针刺治疗组则明显低于安慰针灸组和空白对照组,分别是2.8±1.4,4.3±1.8和4.1±1.9。针刺治疗组的70例中31例临床妊娠,怀孕率44.3%;安慰针灸组的70例中19例临床妊娠,怀孕率27.1%;空白对照组的70例中17例临床妊娠,怀孕率24.3%。治疗组的怀孕率显着高于安慰针灸组和空白对照组(P

  [主题词]胚泡移植,妊娠/针灸效应;妊娠率

  Effect of acupuncture on the pregnancy rate in embryo transfe r and

mechanisms: A randomized and control study

  Zhang Mingmin, Huang Guangying, Lu Fu`er, et al. (Affilia ted Tongji

Hospital, Tongji Medical College, Huazhong University of Science & Techno logy,

Hubei Wuhan 430030, China)

  ABSTRACT Objective To observe the effect of acupunct ure on the pregnancy

rate in assisted reproduction therapy such as in-vitro-fe rtilisation (IVF) and

intracytoplasmatic spermatozoen injection (ICSI), and mech anisms. Methods

210 cases undergoing IVF or ICSI were div ided randomly into three groups:

acupuncture treatment group, placebo group and control group. The acupuncture

treatment group and the placebo group were treate d respectively with body

acupuncture and placebo acupuncture before and after em bryo transfer, and in

the control group embryos were transferred without any sup p ortive therapy.

Contraction frequency of the uterine junctional zone and the pre gnancy rate

were observed. Results The contraction freque ncy before embryo transfer was

not significantly different among the three group s, but after embryo transfer

in the acupuncture treatment group was lower than t hat in the placebo group

and the control group, respectively. The pregnancy rate was 44.3% (31/70) in

the acupuncture treatment group, and 27.1% (19/70) in the placebo group and 24.3%

(17/70) in the control group. The pregnancy rate in t he acupuncture treatment

group was significantly higher than that in the placebo acupuncture group and

the control group (P

  2 治疗方法

  2.1 控制性超排卵

  见文献[1]。

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