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电针刺激对心脏手术病人心肌热休克蛋白mRNA基因表达的影响王祥瑞 张腾飞 马曙亮 周 嘉 郁勤燕 杭燕南 孙大金


  [摘 要] 观察电针刺激对心脏手术病人心肌细胞热休克蛋白mrna基因表达的影响。28例asd病人,随机分为针麻组(组ⅰ,n=6),针刺加全麻组(组ⅱ,n=10),和全麻组(组ⅲ,n=9),于转流前10 min,停转流,停转流30 min,停转流1 h测定ckmb。结果:①3组病人停转流和转流后1h ckmb均较转流前明显增加,但组ⅲ的升幅明显高于组ⅰ和组ⅱ;②针刺组hsp70mrna表达高于对照组(p70mrna表达作用。

  [主题词] 电针;心脏外科手术;热休克蛋白质类/代谢;rna,信使/代谢

  effects of electroacupuncture on myocardial cellular hsp70mrna gene expression in patients undergoing cardiac surgery

  wang xiangrui1,zhang tengfei2,ma shuliang1,et al(1. renji hospital affiliated to shanghai second medical university,shanghai 200127;2. teaching and research section of biochemistry,shanghai second medical university)

  [abstract] purpose to observe the effect of electroacupuncture on myocardial cellular hsp70mrna gene expression in patients undergoing cardiac surgery(asd).methods 28 asd patients were randomly divided into 3 groups,i,e,acupuncture anesthesia group(groupⅰ,n=6),acupuncture combined with general anesthesia group(group ⅱ,n=10) and general anesthesia group(groupⅲ,n=9).the sample from left atrium at 10 min before cpb,stopping cpb,30 min and 1 h after stopping cpb.extration of total rna from myocardial tissue using reagent kit.the concentration of mrna was measured through rtpcr and ckmb was detected.results after cpb ckmb in the three groups was significantly higher than the value of 10 min before cpb,and ckmb in the group ⅲ was remarkedly higher than the group ⅰ and ⅱ;hsp70mrna expression was found to be higher in the group ⅰ than that of group ⅲ at 30 min and 1 h after stopping cpb.conclusion electroacupuncture can induce the expression of hsp70mrna in ischemic myocardial tissue of patients undergoing cardiac surgery.

  [key words] electroacupuncture;heart surgery;rna,massenger/metab;heatshock proteins/metab;myocardium/metab

  体外循环心脏手术术后并发症的发生率与术中心肌缺血、缺氧的保护有明显关系[1]。

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