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电针对MCAO大鼠脑内GAP-43和突触囊泡蛋白表达的影响陈英辉 黄显奋


  [摘要]方法:将实验大鼠分为假手术组、缺血再灌组和缺血再灌+电针组,大脑中动脉线栓(mcao)造成局灶性缺血90min,电针组在缺血后立即给予电针1 h,以后每天1次。在缺血再灌1,7和14天分别处死,进行免疫组织化学染色。结果:gap-43和突触囊泡蛋白主要在缺血灶周围的皮质表达。在再灌后7和14天后电针组gap-43和突触囊泡蛋白免疫阳性细胞数高于缺血再灌组(p<0.05)。结论:电针能够提高gap-43和突触囊泡蛋白在缺血灶周围皮质的表达,从而促进缺血后轴突的出芽和突触的形成,提高了缺血后神经元可塑性。

  [主题词]电针;生长结合蛋白-43*;突触膜糖蛋白/代谢;再灌注损伤/针灸疗法effect of electroacupuncture on gap-43 and synaptophysin expression of ischemic brain in the mcao rat

  chen yinghui, huang xianfen (department of neurobiology, shanghai medical university, shanghai 200032, china)

  [abstract]purpose to observe the effect of electroacupuncture (ea) on growth-associated protein (gap-43) and synaptophysin expression of ischemic brain in the rat by immunohistochemical method. methods the experiment was divided into three groups: sham operation group, ischemia group and ischemia plus ea group. the middle cerebral artery (mca) was occluded for 90 min to result in the local ischemia. ea was applied for one hour immediately after cerebral ischemia. then ea was applied every day till the rats were decapitated after reperfusion for 1,7 and 14 days, respectively. immunohistochemical method was used. results gap-43 and synaptophysin immunoreactive cells expressed mainly in the surrounding cortex of infarction. in the ea group gap-43 and synaptophysin immunoreactive cells after reperfusion for 7 and 14 days were significantly higher than those in the ischemia group (p<0.05).conclusion ea may increase expression of gap-43 and synaptophysin in the surrounding cortex of infarction, so ea can promote the neuronal sprouting and synaptogenesis after ischemia, and improve the neuronal plasticity.

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