关键词：模糊控制； 基因网络； 差异表达基因
Construction of fuzzy gene net
SUN Liang, LI Qingshuo, LI Jiangeng, DUAN Yanhua
(College of Electronic Information & Control Engineering， Beijing University of Technology, Beijing 100022, China)
Abstract:This paper put forward a novel method to forecast gene net that was inducing fuzzy theory.Firstly，permutation test was used to identify differently expressed genes after eliminating noise signal. Then the importance of a gene in classifying the normal and tumor was estimated based on the gene’s entropy. In detail,negative big（NB）,negative middle（NM）, negative small（NS）,zero（0）,positive small（PS）,positive middle（PM）, positive big（PB）7 ranks were introduced to sort the different gene expression values. The relations between two genes were figured by seven “ifthen” rules according to genes’ expression values. In conclusion，a new method to construct fuzzy gene net model was introduced and it was useful to comprehend the occurrence and development of tumor and cancer. At last, MDM2p53 fuzzy gene net is succeeding in describing the relations between them.......